FP1
Focused Plenary I - Pre-Clinical Discovery
Monday, March 30, 2015: 10:15 AM-11:15 AM
Continental Ballroom (Hilton Chicago)
Description: A session focused on pre-clinical discovery that infuses the presentations of the latest research and science in gynecologic oncology with educational components and builds attendee competence in practical application of the science presented.
Moderators: Ernst Lengyel, MD, University of Chicago Medicine, Chicago, IL and Dmitriy Zamarin, MD, Memorial Sloan Kettering Cancer Center, New York, NY
10:15 AM
Moderator
D. Zamarin
Memorial Sloan Kettering Cancer Center, New York, NY
10:15 AM
Introductory Remarks
E. Lengyel
University of Chicago Medicine, Chicago, IL
10:20 AM
Post-chemotherapy tumors in the PDX model identify ribosomal synthesis as a novel targeting strategy in ovarian cancer
Z. C. Dobbin1, A. A. Katre1, D. H. Jeong2, B. K. Erickson1, R. D. Alvarez1, D. A. Schneider1 and C. N. Landen Jr.3
1University of Alabama at Birmingham, Birmingham, AL, 2Busan Paik Hospital, Inje University, Busan, South Korea, 3University of Virginia School of Medicine, Charlottesville, VA
10:29 AM
Pre-surgical window study of metformin in obesity-driven endometrial cancer
V. N. Sivalingam1, R. McVey2, S. Kitson1, K. Gilmour3, S. Ali4, C. Roberts1, A. G. Renehan1, H. Kitchener1 and E. J. Crosbie1
1University of Manchester, Manchester, United Kingdom, 2Central Manchester University Hospitals Foundation Trust, Manchester, United Kingdom, 3Tameside Hospital NHS Foundation Trust, Manchester, United Kingdom, 4Pennine Acute Hospitals NHS Trust, Oldham, United Kingdom
10:38 AM
Synthetic lethality of PARP inhibitors and metformin in BRCA1 intact ovarian cancer
M. Hijaz1, J. Chhina2, S. Dar2, C. Tebbe2, Z. Al-Wahab3, R. K. Hanna2, R. Rattan2 and A. R. Munkarah2
1Henry Ford Hospital, Detroit, MI, 2Henry Ford Health System, Detroit, MI, 3Wayne State University, Detroit, MI
10:47 AM
The effects of NT1014, a novel AMPK activator, compared to metformin, on ovarian cancer cell proliferation, apoptosis, and tumor growth
W. Z. Wysham1, J. E. Kilgore2, A. L. Jackson3, H. Qiu1, C. Zhou1, K. W. Batchelor4 and V. L. Bae-Jump1
1University of North Carolina at Chapel Hill, Chapel Hill, NC, 2Houston Methodist Hospital, Houston, TX, 3University of Cincinnati, Cincinnati, OH, 4NovaTarg Therapeutics, Research Triangle Park, NC
10:56 AM
Distillation
E. Lengyel
University of Chicago Medicine, Chicago, IL
